Natural stone mosaic

I want to use a 1" hex marble on my bathroom floor. I've been told the floor is good enough for ceramic, but not stone. Joists are 16 foot 2x12s with 3/4" plywood subfloor. I plan to use Ditra as an underlayment. Is it true that stone is a problem, even with a mosaic? I could see where deflection would be a problem with a larger tile.

If your using ditra, schluter wants you to add a layer of min. 3/8 ply over the 3/4 for stone. That being said, minimum recommended tile size over ditra is 2"x2".

Thanks! Adding an extra layer of plywood will be easy and I can get 2" hex instead of 1"

Appreciate the help.

Also think bout your cuts along walls and such those pieces are not always gonna be at least two inches, Are you dead set on using mosaic on the floor, I think if you want ditra you need to use a bigger tile!